Research Scientist 1, Bioinformatics

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Reports To: Research Scientist 2, Bioinformatics

Position Type: Salaried, negotiable according to experience and fit; package includes company stock options, as well as tax advantaged employee benefit plans.

Tocagen is a clinical-stage, cancer-selective gene therapy company focused on developing first-in-class, broadly applicable product candidates designed to activate a patient’s immune system against their own cancer from within.

Every member of our team plays a significant role in our success. Tocagen hires individuals who share our passion for ending cancer mortality and have exceptional talent that will contribute to this goal.


The Research Scientist 1, Bioinformatics demonstrates expertise in genomic analyses, preferably with a research background in oncology and/or immunology. This scientist will support projects that aim (i) to identify molecular markers that are predictive of patient response following treatment with Tocagen’s propriety gene therapy technology and (ii) to characterize virus-host interactions, in patients’ tumors and cell culture systems. The primary responsibility of this position is to help program and analyze genomics data coming out of key clinical trials.

Duties and Responsibilities Include But Are Not Limited To:

  • Develops and optimizes robust workflows for next-generating sequencing datasets, including DNA and RNA sequencing.
  • Identifies molecular features from genomics datasets that correlate with clinical outcomes.
  • Works on informatics problems of diverse scope, including novel genomics applications.
  • Reads pertinent scientific journals and articles, maintains relevant current scientific awareness, prepares written reports and in collaboration with other scientists, and writes original proposals for research projects.
  • Significantly contributes to defined documentation practices in support of regulatory filings, white papers, patent filings, publications, grants and other company documents.
  • Co-authors scientific papers and/or journal articles and present research results to colleagues at scientific meetings.
  • Performs other duties as required.

Desired Knowledge and Abilities:

  • Expertise in analysis of human next-generation sequencing data and knowledge of best practices.
  • Competency in informatics-related programming languages and interfaces such as Python, Perl, R and Linux.
  • Familiarity with publicly and commercially available bioinformatics tools.
  • Requires knowledge of discipline including knowledge of protocols, scientific method and its applications, and use of specialized equipment.
  • Demonstrated potential for technical proficiency, scientific creativity, collaboration with others, and independent thought.
  • Enjoys working in a fast paced, dynamic environment.
  • Excellent verbal/written communication skills.
  • Well-organized.
  • Strong theoretical and practical understanding of immunotherapy and biomarkers preferred but not required.

Education & Experience:

  • Ph.D. or equivalent breadth of experience and understanding in Bioinformatics or related scientific discipline.

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