Publications and Presentations

Tocagen’s research and technology has been included in numerous peer-reviewed scientific journals and presented at scientific and medical meetings. Browse the articles and presentations below to learn more.

Long-term follow-up data from 126 patients with recurrent high grade glioma from three Phase 1 trials of Toca 511 and Toca FC: Update and justification for a Phase 2/3 trial.
ASGCT podium presentation by Douglas Jolly, Ph.D., executive vice president of research and pharmaceutical development at Tocagen.
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TOCA 511 & 5-FC: Anti-tumor activity, immune memory and prolonged survival even at low infection levels.
ASGCT poster presentation by Kader Yagiz, Ph.D., research scientist at Tocagen.
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Toca 511 gene transfer and treatment with the prodrug, 5-fluorocytosine, promotes durable antitumor immunity in a mouse glioma model
Neuro-Oncol.
Published online: April 6, 2017
Leah A. Mitchell, et al.
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Retroviral replicating vector–mediated gene therapy achieves long-term control of tumor recurrence and leads to durable anticancer immunity
Neuro-Oncol.
Published online: April 6, 2017
Kei Hiraoka, et al.
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Retroviral replicating vector delivery of miR-PDL1 inhibits immune checkpoint PDL1 and enhances immune responses in vitro
Mol. Ther. — Nucleic Acids.
Published online: Feb. 8, 2017
Amy H. Lin, et al.
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Phase 1 trial of vocimagene amiretrorepvec and 5-fluorocytosine for recurrent high-grade glioma.
Sci. Transl. Med.
2016; 8(341): 341ra75.
Timothy F. Cloughesy, et al.
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MethylMeter: bisulfite-free quantitative and sensitive DNA methylation profiling and mutation detection in FFPE samples.
Epigenomics.
2016;8(6):747-765.
David McCarthy, …Oscar Diago, et al.
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Toca 511 plus 5-fluorocytosine in combination with lomustine shows chemotoxic and immunotherapeutic activity with no additive toxicity in rodent glioblastoma models.
Neuro-Oncol.
2016;18(10):1390-1401.
Kader Yagiz, et al.
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Extensive Replication of a Retroviral Replicating Vector Can Expand the A Bulge in the Encephalomyocarditis Virus Internal Ribosome Entry Site and Change Translation Efficiency of the Downstream Transgene.
Hum. Gene Ther. Methods
2016;27(2):59-70.
Lin AH. et al.
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Retroviral Replicating Vectors Deliver Cytosine Deaminase Leading to Targeted 5-Fluorouracil-Mediated Cytotoxicity in Multiple Human Cancer Types.
Hum. Gene. Ther. Methods
2016;27(1):17-31.
Twitty CG. et al.
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Intravenous administration of a retroviral replicating vector, Toca 511, demonstrates therapeutic efficacy in an orthotopic immune-competent mouse glioma model.
Hum. Gene Ther.
2015;26(2): 82-93.
Huang T. et al.
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Blockade of Type I Interferon (IFN) Production by Retroviral Replicating Vectors and Reduced Tumor Cell Responses to IFN Likely Contribute To Tumor Selectivity.
J Virol.
2014; 88(17): 10066-10077.
Lin AH. et al.
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Radiosensitization of gliomas by intracellular generation of 5-fluorouracil potentiates prodrug activator gene therapy with a retroviral replicating vector.
Cancer Gene Ther.
2014; 21(10): 405-410.
Takahashi M. et al.
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MicroRNA 142-3p Attenuates Spread of Replicating Retroviral Vector in Hematopoietic Lineage-Derived Cells While Maintaining an Antiviral Immune Response.
Hum. Gene Ther.
2014;25(8):759-771.
Lin AH. et al.
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Maintaining therapeutic activity in the operating room: compatibility of a gamma-retroviral replicating vector with clinical materials and biofluids.
Mol. Ther. — Methods & Clinical Development.
2014; 1, 14024.
Burnett R. et al.
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Toca 511 gene transfer and 5-fluorocytosine in combination with temozolomide demonstrates synergistic therapeutic efficacy in a temozolomide-sensitive glioblastoma model.
Cancer Gene Ther.
2013; 20(10): 544-551.
Huang TT. et al.
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Convection-enhanced delivery improves distribution and efficacy of tumor-selective retroviral replicating vectors in a rodent brain tumor model.
Cancer Gene Therapy.
2013; 20(6): 336–334.
Dali Yin,….Harry E. Gruber, et al.
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Not Reinventing the Wheel: Applying the 3Rs Concepts to Viral Vector Gene Therapy Biodistribution Studies.
Human Gene Ther. Clin. Dev.
2013; 24: 1–4.
Timothy K. MacLachlan,…DJ. Jolly, et al.
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Design and Selection of Toca 511 for Clinical Use: Modified Retroviral Replicating Vector With Improved Stability and Gene Expression.
Mol. Ther.
2012; 20(9): 1689-1698.
Perez O. and Logg C. et al.
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(2012) Chapter 11: Retroviral Replicating Vectors in Cancer, in Friedmann T.
(ed) Gene Transfer Vectors for Clinical Application, Academic Press, 199-228.
Logg, C. R. et al.
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Brain tumor eradication and prolonged survival from intratumoral conversion of 5-fluorocytosine to 5-fluorouracil using a nonlytic retroviral replicating vector.
Neurooncol.
2012; 14(2): 145-159.
Ostertag D. et al.
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