Tocagen is committed to fighting brain cancer. Recurrent high grade glioma, or HGG, is the most common and aggressive primary brain cancer and often strikes in the prime of life. The total number of new diagnoses of HGG expected in 2017 is about 160,000 worldwide and about 14,000 in the United States, and the two most common forms of HGGs are glioblastoma, or GBM, and anaplastic astrocytoma, or AA.
Standard of care for newly diagnosed HGG is surgical removal of as much of the tumor as possible followed by radiation therapy and an alkylating drug, temozolomide. Unfortunately, HGG recurs in most patients, even after maximal treatment. Patients may find it empowering to plan ahead with their care team to determine which options may be suitable for them in the event of a recurrence, including consideration of a clinical trial.
Tocagen is conducting a clinical trial, called Toca 5, for patients with recurrent GBM or AA who are planning to have their tumor removed surgically. Enrollment completed in the Phase 2 portion of the Phase 2/3 study in February 2017 and Tocagen plans to report top line results in the first half of 2018.
Learn more on our clinical trials page, contact us through our patient inquiry form for more information about this trial.