Scientific Publications

Huang T. et al. Intravenous administration of a retroviral replicating vector, Toca 511, demonstrates therapeutic efficacy in an orthotopic immune-competent mouse glioma model. Hum. Gene Ther. 2015; 26(2): 82-93. Read the abstract.

Lin AH. et al. Blockade of Type I Interferon (IFN) Production by Retroviral Replicating Vectors and Reduced Tumor Cell Responses to IFN Likely Contribute To Tumor Selectivity. J Virol. 2014; 88(17): 10066-10077. Read the abstract.

Takahashi M. et al. Radiosensitization of gliomas by intracellular generation of 5-fluorouracil potentiates prodrug activator gene therapy with a retroviral replicating vector. Cancer Gene Ther. 2014; 21(10): 405-410. Read the abstract.

Lin AH. et al. MicroRNA 142-3p Attenuates Spread of Replicating Retroviral Vector in Hematopoietic Lineage-Derived Cells While Maintaining an Antiviral Immune Response. Hum. Gene Ther. 2014; 25(8):759-771. Read the abstract.

Burnett R. et al. Maintaining therapeutic activity in the operating room: compatibility of a gamma-retroviral replicating vector with clinical materials and biofluids. Mol. Ther. — Methods & Clinical Development. 2014; 1, 14024. Read the article.

Huang TT. et al. Toca 511 gene transfer and 5-fluorocytosine in combination with temozolomide demonstrates synergistic therapeutic efficacy in a temozolomide-sensitive glioblastoma model. Cancer Gene Ther. 2013; 20(10): 544-551. Read the abstract.

Yin D. et al. Convection-enhanced delivery improves distribution and efficacy of tumor-selective retroviral replicating vectors in a rodent brain tumor model. Cancer Gene Ther. 2013; 20(6): 336-341. Read the article.

Perez O. and Logg C. et al. Design and Selection of Toca 511 for Clinical Use: Modified Retroviral Replicating Vector With Improved Stability and Gene Expression. Mol. Ther. 2012; 20(9): 1689-1698. Read the article.

Logg, C. R. et al. (2012) Chapter 11: Retroviral Replicating Vectors in Cancer, in Friedmann T. (ed) Gene Transfer Vectors for Clinical Application, Academic Press, 199-228. Read the abstract.

Ostertag D. et al. Brain tumor eradication and prolonged survival from intratumoral conversion of 5-fluorocytosine to 5-fluorouracil using a nonlytic retroviral replicating vector. Neurooncol. 2012; 14(2): 145-159. Read the article. Read the supplementary data.